The following is a list of significant lead guitarists, arranged in ascending alphabetical order of their last name. For rhythm guitarists see list of rhythm guitarists.
This list is incomplete; you can help by expanding it.
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- Dave Sabo (Skid Row)
- Richie Sambora (Bon Jovi)
- Karl Sanders (Nile)
- Carlos Santana (Santana)
- Joey Santiago (Pixies)
- Ralph Santolla
- Joe Satriani
- Michael Schenker (Scorpions, UFO, Michael Schenker Group)
- Neal Schon (Journey)
- Chuck Schuldiner (Death, Control Denied)
- Keith Scott (Bryan Adams)
- Brian Setzer (The Stray Cats)
- James "Munky" Shaffer (Korn)
- Todd Sharpville
- Justin Shekoski (Saosin)
- Hank Shermann (Mercyful Fate)
- Kevin Shields (My Bloody Valentine)
- Charlie Simpson (Fightstar, Busted)
- Alex Skolnick (Testament, Trans Siberian Orchestra)
- Slash (Guns N\' Roses, Velvet Revolver)
- Martin Slattery (The Mescaleros)
- Snail\'s Pace Slim (The Hamsters)
- Adrian Smith (Iron Maiden)
- Robert Smith (The Cure)
- Bruce Springsteen (E Street Band)
- Billy Squier
- Muhammed Suiçmez (Necrophagist)
- John Squire (The Stone Roses, The Seahorses)
- Mark St. John (KISS)
- Bill Steer (Carcass)
- Leigh Stephens (Blue Cheer, Sister Ray)
- Travis Stever (Coheed and Cambria)
- Stephen Stills (Buffalo Springfield, Crosby, Stills, Nash and Young)
- Jeff Stinco (Simple Plan)
- Andrew Stockdale (Wolfmother)
- Sugizo (Luna Sea, S.K.I.N.)
- Sek Loso (Loso)
- Andy Summers (The Police)
- Bernard Sumner (Joy Division, New Order)
- Red Symons (Skyhooks)
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